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CBD entourage effect is one of the widely discussed issues in the CBD industry. It was first used by Dr. Raphael Mechoulam, a renowned Israeli biochemist in 1998 and can be described as a speculation where combining cannabis compounds can create a different physical or psychological impact than a single compound on its own. It can also be defined as a situation where people combine one or more compounds extracted from the cannabis plant to elicit more functions.

While a lot of patients have testified to experiencing better results by using the whole cannabis plant or combined cannabinoid therapy, these speculations or thesis may need to undergo more scientific and clinical research. To understand if entourage effect is real or not, let’s take you on journey of discovery about the cannabis plants and its numerous phytocannabinoids.

Cannabis Sativa L. species is a large group of plants including hemp and marijuana. They have been found to contain a high level of phytochemicals including terpenoids, alkaloids and cannabinoids which can interact with the mind and body at various concentrations and degrees. At the time of writing this article, there are over 100 different cannabinoids identified in the cannabis plant. These compounds include but are not limited to tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN) and Cannabigerol (CBG). Out of this vast number, only psychoactive THC and non-intoxicating CBD has gained the attention of researchers and consumers. The presence of terpenoids/terpenes in the cannabis plant, gives it a distinctive smell and flavor. All the different cannabinoids and terpenes present in the cannabis plant tend to have their unique functions and some researchers believed they can combine these activities to create a more potent drug for the treatment of diseases and infections in human and pet populations.

One of such scientists Dr. Ethan Russo published a 2011 paper which investigated the possible interactions between cannabinoids and terpenes which searching for a synergistic effect to treat pain, anxiety, addiction, epilepsy, cancer, depression and bacterial infections. After the results of his experiments, in 2008 and 2011 many CBD users believe that a synergistic effect between cannabinoids is more beneficial and can elicit better activities. This also led to the conclusion that full spectrum CBD products (products containing all the cannabinoids and terpenes from the cannabis plant) are the best for all cannabis-based medications.

While these speculations have taken roots as an authority, it will interest you to note that full spectrum CBD compounds do not produce the best CBD-based medicines. The use of pure CBD isolates is far more active and beneficial than the whole plant and entourage effect may just be another prediction gone wrong. This may be contrary the beliefs of alternative medicine which revolves around the use of whole plants for better activity.

Please note, the cannabinoids may produce a synergistic effect while combined together but this should not form the basis of using the whole plant for medication as there is need to conduct more scientific research to prove this claims.


Entourage effect may be real but until certified by the right body we believe it is still a mere assumption. Kindly contact us if you have questions on combined CBD therapy, we will love to hear from you.